A Novel Spectrophotometric Method for the Determination of Isoniazid Using Cu(Ⅱ)as Spectroscopic Probe Ion

A novel method to determine isoniazid with high sensitivity and good selectivity has been established by using Cu(Ⅱ)as a spectroscopic probe ion.The experiment indicated that Cu(Ⅱ)Was reduced to Cu(Ⅰ)by isoniazid at pH 6.0,then the resulting Cu(Ⅰ)was precipitated with SCN- to form CuSCN that could be stayed upon the surface of water phase in the presence of NaN03.By determining the residual amount of Cu(Ⅱ)in the water phase,the indirect determination of isoniazid could be achieved.Good linear relationship between the amount of the reacted Cu(Ⅱ)and the concentration of isoniazid Was observed.with the linear range being 0.050-4.50μg·mL-1,and the detec-tion limit being 0.048μg·mL-1.This method has been successfully applied to determining isoniazid among phar-maceutical samples and patient urine samples.

作 者： ZHANG,Hua ZHANG,Yan WEI,Xianjun DU,Xinzhen LI,Quanmin   作者單位： ZHANG,Hua(College of Chemistry and Environmental Science,Henan Normal University,Xinxiang,Henan 453007,China;College of Chemistry and Chemical Engineering, Northwest Normal University,Lanzhou,Gansu 730070,China)

ZHANG,Yan(College of Chemitry and Chemical Engineering,Henan Institute of Science and Technology,Xinxiang,Henan 453003,China)

WEI,Xianjun,LI,Quanmin(College of Chemistry and Environmental Science,Henan Normal University,Xinxiang,Henan 453007,China)

DU,Xinzhen(College of Chemistry and Chemical Engineering, Northwest Normal University,Lanzhou,Gansu 730070,China) 

刊 名： 中國化學（英文版）  SCI 英文刊名： CHINESE JOURNAL OF CHEMISTRY  年，卷(期)： 2009 27(3)  分類號： O6  關鍵詞： Cu(Ⅱ)   spectroscopic probe ion   isoniazid   spectrophotometry  

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