Interactions of the HSV-1 UL25 Capsid Protein with Cellular Microtubule-associated Protein

An interaction between the HSV-1 UL25 capsid protein and cellular microtubule-associated protein was found using a yeast two-hybrid screen and β-D-galactosidase activity assays. Immunofluorescence microscopy of the UL25 protein demonstrated its co-localization with cellular microtubule-associated protein in the plasma membrane. Further investigations with deletion mutants suggest that UL25 is likely to have a function in the nucleus.

作 者： Lei GUO Ying ZHANG Yan-chun CHE Wen-juan WU Wei-zhong LI Li-chun WANG Yun LIAO Long-ding LIU Qi-han LI   作者單位： Institute of Medical Biology, Chinese Academy of Medical Sciences, Peking Union Medical College, Kunming 650118, China  刊 名： 中國病毒學  ISTIC 英文刊名： VIROLOGICA SINICA  年，卷(期)： 2008 23(3)  分類號： Q7  關鍵詞： HSV-1   Capsid   UL25   Microtubule-associated protein