Cu(Ⅰ)-catalyzed Synthesis of Diaryl Ether Using a Simple Hydrazone as Promoter

A simple hydrazone-type ligand, 2-pyridinecarboxaldehyde phenylhydrazone 1, was found to significantly promote the Cu(Ⅰ)-catalyzed coupling reaction between aryl bromides and phenols. This cross-coupling reaction occurred in di-oxane in 90-100 ℃ in the presence of K3PO4 as base, with a broader substrate scope including electron-poor, -neutral or -rich aryl bromides as well as a high tolerance of base-sensitive functionalities such as ester, aldehyde and ketone.

作 者： LIU Yuhua LI Gang YANG Lianming   作者單位： LIU Yuhua,LI Gang(Beijing National Laboratory for Molecular Sciences BNLMS & Laboratory of New Materials,Institute of Chemistry,Chinese Academy of Sciences,Beijing I00080,China;Graduate School of Chinese Academy of Sciences,Beijing 100049,China)

YANG Lianming(Beijing National Laboratory for Molecular Sciences BNLMS & Laboratory of New Materials,Institute of Chemistry,Chinese Academy of Sciences,Beijing I00080,China) 

刊 名： 中國化學（英文版）  SCI 英文刊名： CHINESE JOURNAL OF CHEMISTRY  年，卷(期)： 2009 27(2)  分類號： O6  關鍵詞： copper-catalyzed cross-coupling   hydrazone-type ligand   diaryl ether synthesis  

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