Effects of polypeptide from Chlamys farreri on amino acid content in guinea pig skin irradiated by chronic ultraviolet A

We examined the effects of polypeptide from Chlamys farreri (PCF) on the amount of hydroxyproline in guinea pig skin irradiated by chronic ultraviolet A (UVA) and ultraviolet B (UVB) radiation. PCF was applied locally before repeated exposure of guinea pig to UVA and UVB. The contents of hydroxyproline and other amino acids in guinea pig skin were determined by automatic amino acid analyzer. Our results showed that: (1) long-time UVA and UVB radiation can reduce dramatically the amounts of hydroxyproline, aspartic acid, threonine, glycine, phenylalanine and lysine in guinea pig skin in comparison with the control group (P < 0.05); (2) Compared with model group, pre-treatment with 5 % and 20 % PCF prior to UVA and UVB radiation can inhibit the decline of amino acids content in guinea pig skin in a dose-dependent manner (P < 0.05). As the decrease of hydroxyproline, glycine and lysine contents in the skin directly reflexes type I collagen degeneration, our results indicated that the chronic application of PCF can protect skin type I collagen against UV radiation, and thus protect skin from photoaging.

作 者： YU Guoying CAO Pengli GUO Kun Wang Yuejun SUN Mi WANG Chunbo   作者單位： Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, China  刊 名： 中國海洋湖沼學報（英文版）  ISTIC SCI 英文刊名： CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY  年，卷(期)： 2004 22(4)  分類號： P7  關鍵詞： polypeptide from Chlamys farreri   ultraviolet radiation   hydroxyproline   photoaging   guinea pig  

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