Reduced cell death by inosine pretreatment after photochemically induced cerebral ischemia in adult rats

Protective effect of inosine against cell death after photochemically induced focal cerebral ischemia was investigated in adult rats.Intraperitoneal injection of inosine was started 24 h before operation and continued till the animals were sacrificed.The TUNEL method and Nissl staining were used to identify apoptosis and necrosis,respectively.TUNEL-positive cells were located in the transitional zone between the necrotic core and normal cortex.The mean maximum area of the necrotic cores and mean number of TUNEL-positive cells 24 h after operation were reduced significantly in the inosine-treated rats when compared with those in the saline-treated control animals.We suggest that inosine can significantly reduce both necrosis and apoptosis following cerebral ischemia induced by photothrombosis in adult rats.

作 者： Zhongliang Wu Fei Liu Yazhou Wang Xiying Jiao Ming Shi Qingbo Zhao Gong Ju Siwei You   作者單位： Zhongliang Wu,Fei Liu,Yazhou Wang,Xiying Jiao,Ming Shi,Gong Ju,Siwei You(Institute of Neurosciences,The Fourth Military Medical University,17 Changlexi Road, Xi'an 710032, China)

Qingbo Zhao(Department of Biostatistics, The Fourth Military Medical University, 17 Changlexi Road, Xi'an 710032,China) 

刊 名： 自然科學進展（英文版）  SCI 英文刊名： PROGRESS IN NATURAL SCIENCE  年，卷(期)： 2008 18(12)  分類號： N1  關鍵詞： Cell death   Cerebral infarction   Inosine   Photothrombosis   Rat  

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